cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple cell types. 5hmC is converted from 5-methylcytosine (5mC) by...

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Publicado en:eLife
Autores principales: Camarena, Vladimir, Sant, David W, Huff, Tyler C, Mustafi, Sushmita, Muir, Ryan K, Aron, Allegra T, Chang, Christopher J, Renslo, Adam R, Monje, Paula V, Wang, Gaofeng
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745079/
https://ncbi.nlm.nih.gov/pubmed/29239726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29750
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