The anti-tumorigenic activity of A2M—A lesson from the naked mole-rat

Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat’s cancer resistance. N...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Kurz, Susanne, Thieme, René, Amberg, Ronny, Groth, Marco, Jahnke, Heinz-Georg, Pieroh, Philipp, Horn, Lars-Christian, Kolb, Marlen, Huse, Klaus, Platzer, Matthias, Volke, Daniela, Dehghani, Faramarz, Buzdin, Anton, Engel, Kathrin, Robitzki, Andrea, Hoffmann, Ralf, Gockel, Ines, Birkenmeier, Gerd
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744951/
https://ncbi.nlm.nih.gov/pubmed/29281661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189514
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