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An expanded population of pathogenic regulatory T-cells in giant cell arteritis is abrogated by IL-6 blockade therapy
OBJECTIVES: Randomized-controlled trials have recently proven the efficacy of the interleukin-6 receptor antagonist tocilizumab (TCZ) in GCA. However, the mechanism of action of IL-6 blockade in this disease is unknown. Moreover, the role of regulatory T-cells (Treg) in the pathogenesis of GCA remai...
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| 出版年: | Ann Rheum Dis |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5744591/ https://ncbi.nlm.nih.gov/pubmed/27927642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2016-210070 |
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