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Theory Meets Experiment: Metal Ion Effects in HCV Genomic RNA Kissing Complex Formation
The long-range base pairing between the 5BSL3. 2 and 3′X domains in hepatitis C virus (HCV) genomic RNA is essential for viral replication. Experimental evidence points to the critical role of metal ions, especially Mg(2+) ions, in the formation of the 5BSL3.2:3′X kissing complex. Furthermore, NMR s...
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| Pubblicato in: | Front Mol Biosci |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5744182/ https://ncbi.nlm.nih.gov/pubmed/29312955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2017.00092 |
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