Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes

Chronic granulomatous disease (CGD) is caused by mutations in genes that encode the NADPH-oxidase and result in a failure of phagocytic cells to produce reactive oxygen species (ROS) via this enzyme system. Patients with CGD are highly susceptible to infections and often suffer from inflammatory dis...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Sundqvist, Martina, Christenson, Karin, Björnsdottir, Halla, Osla, Veronica, Karlsson, Anna, Dahlgren, Claes, Speert, David P., Fasth, Anders, Brown, Kelly L., Bylund, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744066/
https://ncbi.nlm.nih.gov/pubmed/29375548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01828
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