Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke

In response to stroke-induced injury, astrocytes can be activated and form a scar. Inflammation is an essential component for glial scar formation. Previous study has shown that adjudin, a potential Sirt3 activator, could attenuate lipopolysaccharide (LPS)- and stroke-induced neuroinflammation. To i...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Yang, Xiao, Geng, Keyi, Zhang, Jinfan, Zhang, Yanshuang, Shao, Jiaxiang, Xia, Weiliang
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744009/
https://ncbi.nlm.nih.gov/pubmed/29311941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00943
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