Genetic Inhibition of PPARγ S112 Phosphorylation Reduces Bone Formation and Stimulates Marrow Adipogenesis()

A common feature of many skeletal diseases is the accumulation of marrow fat. A reciprocal relationship exists between osteogenesis and adipogenesis in bone marrow that is mediated by the relative activity of PPARγ and RUNX2 transcription factors. The ERK/MAPK pathway is an important inducer of MSC...

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Bibliographische Detailangaben
Veröffentlicht in:Bone
Hauptverfasser: Ge, Chunxi, Zhao, Guisheng, Li, BinBin, Li, Yan, Cawthorn, William P., MacDougald, Ormond A., Franceschi, Renny T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743762/
https://ncbi.nlm.nih.gov/pubmed/29107124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2017.10.023
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