KPNA2 promotes migration and invasion in epithelial ovarian cancer cells by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail activation

Background: Increased karyopherin alpha 2 (KPNA2) expression has been demonstrated in epithelial ovarian carcinoma (EOC) tissue. However, its role in the disease is not clear. Here, we investigate the mechanism of involvement of KPNA2 in EOC. Methods: Stable cell lines expressing KPNA2, or KPNA2 shR...

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Bibliographic Details
Published in:J Cancer
Main Authors: Huang, Long, Zhou, Yun, Cao, Xin-Ping, Lin, Jia-Xin, Zhang, Lan, Huang, Shu-Ting, Zheng, Min
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743723/
https://ncbi.nlm.nih.gov/pubmed/29290781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.20879
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