Bio-Catalytic Structural Transformation of Anti-cancer Steroid, Drostanolone Enanthate with Cephalosporium aphidicola and Fusarium lini, and Cytotoxic Potential Evaluation of Its Metabolites against Certain Cancer Cell Lines

In search of selective and effective anti-cancer agents, eight metabolites of anti-cancer steroid, drostanolone enanthate (1), were synthesized via microbial biotransformation. Enzymes such as reductase, oxidase, dehydrogenase, and hydrolase from Cephalosporium aphidicola, and Fusarium lini were lik...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Choudhary, M. Iqbal, Siddiqui, Mahwish, Atia-tul-Wahab, Yousuf, Sammer, Fatima, Narjis, Ahmad, Malik S., Choudhry, Hani
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742531/
https://ncbi.nlm.nih.gov/pubmed/29326586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00900
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