Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and pro-arrhythmia risk. Methods: Adult human primary...

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Publicat a:Front Physiol
Autors principals: Nguyen, Nathalie, Nguyen, William, Nguyenton, Brynna, Ratchada, Phachareeya, Page, Guy, Miller, Paul E., Ghetti, Andre, Abi-Gerges, Najah
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742250/
https://ncbi.nlm.nih.gov/pubmed/29311989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.01073
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