Bruch’s Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is the leading cause of blindness in the western world and affects nearly 200 million people globally. Local inflammation driven by complement system dysregulation is currently a therapeutic target. Bruch’s membrane (BrM) is a sheet of extracellular matrix that...

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Vydáno v:Front Immunol
Hlavní autoři: Clark, Simon J., McHarg, Selina, Tilakaratna, Viranga, Brace, Nicole, Bishop, Paul N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742201/
https://ncbi.nlm.nih.gov/pubmed/29312308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01778
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