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Annotation-free quantification of RNA splicing using LeafCutter
The excision of introns from pre-mRNA is an essential step in mRNA processing. We developed LeafCutter to study sample and population variation in intron splicing. LeafCutter identifies variable splicing events from short-read RNA-seq data and finds events of high complexity. Our approach obviates t...
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Publicado no: | Nat Genet |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5742080/ https://ncbi.nlm.nih.gov/pubmed/29229983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-017-0004-9 |
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