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TIEG and estrogen modulate SOST expression in the murine skeleton

TIEG knockout (KO) mice exhibit a female-specific osteopenic phenotype and altered expression of TIEG in humans is associated with osteoporosis. Gene expression profiling studies identified sclerostin as one of the most highly up-regulated transcripts in the long bones of TIEG KO mice relative to WT...

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Détails bibliographiques
Publié dans:J Cell Physiol
Auteurs principaux: Subramaniam, Malayannan, Pitel, Kevin S., Bruinsma, Elizabeth S., Monroe, David G., Hawse, John R.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741473/
https://ncbi.nlm.nih.gov/pubmed/29044507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26211
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