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Characterization of the Rabbit as an In Vitro and In Vivo Model to Assess the Effects of Fibrinogenolytic Activity of Snake Venom on Coagulation

Several in vitro investigations have demonstrated that anticoagulant effects of fibrinogenolytic snake venom metalloproteinases have been abrogated in human plasma by modifying fibrinogen with iron (Fe) and carbon monoxide (CO) to prevent catalysis or by directly inhibiting these enzymes with CO. In...

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Foilsithe in:Basic Clin Pharmacol Toxicol
Main Authors: Nielsen, Vance G., Sánchez, Elda E., Redford, Daniel T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741465/
https://ncbi.nlm.nih.gov/pubmed/28696521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcpt.12848
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