Reduced intraepidermal nerve fiber density after a sustained increase in insular glutamate: a proof-of-concept study examining the pathogenesis of small fiber pathology in fibromyalgia

INTRODUCTION: Neuroimaging reveals increased glutamate within the insula of patients with fibromyalgia (FM), suggesting a link between FM symptoms and increased central excitatory neurotransmission. Many patients with FM also present with decreased intraepidermal nerve fiber density (IENFD), consist...

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Detalhes bibliográficos
Publicado no:Pain Rep
Main Authors: Harte, Steven E., Clauw, Daniel J., Hayes, John M., Feldman, Eva L., St Charles, Irene C., Watson, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2017
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741296/
https://ncbi.nlm.nih.gov/pubmed/29392206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PR9.0000000000000590
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