Characterization of SPP inhibitors suppressing propagation of HCV and protozoa

Signal peptide peptidase (SPP) is an intramembrane aspartic protease involved in the maturation of the core protein of hepatitis C virus (HCV). The processing of HCV core protein by SPP has been reported to be critical for the propagation and pathogenesis of HCV. Here we examined the inhibitory acti...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Hirano, Junki, Okamoto, Toru, Sugiyama, Yukari, Suzuki, Tatsuya, Kusakabe, Shinji, Tokunaga, Makoto, Fukuhara, Takasuke, Sasai, Miwa, Tougan, Takahiro, Matsunaga, Yasue, Yamashita, Kazuo, Sakai, Yusuke, Yamamoto, Masahiro, Horii, Toshihiro, Standley, Daron M., Moriishi, Kohji, Moriya, Kyoji, Koike, Kazuhiko, Matsuura, Yoshiharu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740650/
https://ncbi.nlm.nih.gov/pubmed/29187532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712484114
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