Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection

Oral preexposure prophylaxis (PrEP) has been approved for prophylaxis of HIV-1 transmission but is associated with high costs and issues of adherence. Protection from anal transmission of HIV using topical microbicides and methods congruent with sexual behavior offers the promise of improved adheren...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Xiao, Peng, Gumber, Sanjeev, Marzinke, Mark A., Date, Abhijit A., Hoang, Thuy, Hanes, Justin, Ensign, Laura M., Wang, Lin, Rohan, Lisa, Fuchs, Edward J., Hendrix, Craig, Villinger, Francois
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740373/
https://ncbi.nlm.nih.gov/pubmed/29084755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01644-17
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