Impact of Rifabutin or Rifampin on Bedaquiline Safety, Tolerability, and Pharmacokinetics Assessed in a Randomized Clinical Trial with Healthy Adult Volunteers

Bedaquiline is a diarylquinoline that specifically inhibits mycobacterial ATP synthase. Bedaquiline has been used to effectively treat tuberculosis (TB) caused by drug-susceptible and drug-resistant Mycobacterium tuberculosis. Rifamycins are a cornerstone of combination drug regimens for the treatme...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Healan, Amanda M., Griffiss, J. McLeod, Proskin, Howard M., O'Riordan, Mary Ann, Gray, Wesley A., Salata, Robert A., Blumer, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740348/
https://ncbi.nlm.nih.gov/pubmed/29061739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00855-17
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