mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

OBJECTIVES: There is a critical need to develop effective treatments for diabetic neuropathy. This study determined if a selective mGluR2/3 receptor agonist prevented or treated experimental diabetic peripheral neuropathy (DPN) through glutamate recycling and improved mitochondrial function. METHODS...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Ann Clin Transl Neurol
Prif Awduron: Chandrasekaran, Krish, Muragundla, Anjaneyulu, Demarest, Tyler G., Choi, Joungil, Sagi, Avinash R., Najimi, Neda, Kumar, Pranith, Singh, Anmol, Ho, Cheng‐Ying, Fiskum, Gary, Koch, Lauren G., Britton, Steven L., Russell, James W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740254/
https://ncbi.nlm.nih.gov/pubmed/29296613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.484
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg