mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

OBJECTIVES: There is a critical need to develop effective treatments for diabetic neuropathy. This study determined if a selective mGluR2/3 receptor agonist prevented or treated experimental diabetic peripheral neuropathy (DPN) through glutamate recycling and improved mitochondrial function. METHODS...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Ann Clin Transl Neurol
Egile Nagusiak: Chandrasekaran, Krish, Muragundla, Anjaneyulu, Demarest, Tyler G., Choi, Joungil, Sagi, Avinash R., Najimi, Neda, Kumar, Pranith, Singh, Anmol, Ho, Cheng‐Ying, Fiskum, Gary, Koch, Lauren G., Britton, Steven L., Russell, James W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740254/
https://ncbi.nlm.nih.gov/pubmed/29296613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.484
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