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Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix‐assisted laser desorption ionization mass spectrometry imaging: a pilot study

BACKGROUND AND PURPOSE: The penetration of the anaplastic lymphoma kinase (ALK) inhibitor alectinib in neuroblastomas and the relationship between alectinib and ALK expression are unknown. The aim of this study was to perform a quantitative investigation of the inter‐ and intra‐tumoural distribution...

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Publicat a:Br J Pharmacol
Autors principals: Ryu, Shoraku, Hayashi, Mitsuhiro, Aikawa, Hiroaki, Okamoto, Isamu, Fujiwara, Yasuhiro, Hamada, Akinobu
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740247/
https://ncbi.nlm.nih.gov/pubmed/29027209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14067
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