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Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets

Protein:protein interactions are among the most difficult to treat molecular mechanisms of disease pathology. Cystine-dense peptides have the potential to disrupt such interactions, and are used in drug-like roles by every clade of life, but their study has been hampered by a reputation for being di...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Crook, Zachary R., Sevilla, Gregory P., Friend, Della, Brusniak, Mi-Youn, Bandaranayake, Ashok D., Clarke, Midori, Gewe, Mesfin, Mhyre, Andrew J., Baker, David, Strong, Roland K., Bradley, Philip, Olson, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740061/
https://ncbi.nlm.nih.gov/pubmed/29269835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02098-8
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