A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome

OBJECTIVE: CHF5633 (Chiesi Farmaceutici S.p.A., Parma, Italy) is the first fully synthetic surfactant enriched by peptide analogues of two human surfactant proteins. We planned to assess safety and tolerability of CHF5633 and explore preliminary efficacy. DESIGN: Multicentre cohort study. PATIENTS:...

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Pubblicato in:Arch Dis Child Fetal Neonatal Ed
Autori principali: Sweet, David G, Turner, Mark A, Straňák, Zbyněk, Plavka, Richard, Clarke, Paul, Stenson, Ben J, Singer, Dominique, Goelz, Rangmar, Fabbri, Laura, Varoli, Guido, Piccinno, Annalisa, Santoro, Debora, Speer, Christian P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Archives of Disease in Childhood 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739829/
https://ncbi.nlm.nih.gov/pubmed/28465315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/archdischild-2017-312722
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