Wird geladen...

Mutations in the DNA methylation pathway and number of driver mutations predict response to azacitidine in myelodysplastic syndromes

We evaluated the association of mutations in 34 candidate genes and response to azacitidine in 84 patients with myelodysplastic syndrome (MDS), with 217 somatic mutations identified by next-generation sequencing. Most patients (93%) had ≥1 mutation (mean=2.6/patient). The overall response rate to az...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Cedena, M. Teresa, Rapado, Inmaculada, Santos-Lozano, Alejandro, Ayala, Rosa, Onecha, Esther, Abaigar, María, Such, Esperanza, Ramos, Fernando, Cervera, José, Díez-Campelo, María, Sanz, Guillermo, Rivas, Jesús Hernández, Lucía, Alejandro, Martínez-López, Joaquin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739787/
https://ncbi.nlm.nih.gov/pubmed/29291002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22157
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!