Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML

Internal tandem duplication of the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3-ITD) is the most prevalent genetic aberration present in 20-30% of acute myeloid leukaemia (AML) cases and is associated with a poor prognosis. FLT3-ITD expressing cells express elevated levels of NADPH oxida...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Moloney, Jennifer N., Jayavelu, Ashok Kumar, Stanicka, Joanna, Roche, Sarah L., O'Brien, Rebecca L., Scholl, Sebastian, Böhmer, Frank-D., Cotter, Thomas G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739649/
https://ncbi.nlm.nih.gov/pubmed/29285262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22241
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