Abnormally glycosylated MUC1 establishes a positive feedback circuit of inflammatory cytokines, mediated by NF-κB p65 and EzH2, in colitis-associated cancer

The abnormal hypoglycosylated form of the epithelial mucin MUC1 is over-expressed in chronic inflammation and on human adenocarcinomas, suggesting its potential role in inflammation-driven tumorigenesis. The presence of human MUC1 aggravates colonic inflammation and increases tumor initiation and pr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cascio, Sandra, Faylo, Jacque L., Sciurba, Joshua C., Xue, Jia, Ranganathan, Sarangarajan, Lohmueller, Jason J., Beatty, Pamela L., Finn, Olivera J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739638/
https://ncbi.nlm.nih.gov/pubmed/29285251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22168
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