Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling

γ-aminobutyric acid (GABA) begins as the key excitatory neurotransmitter in newly forming circuits, with chloride efflux from GABA type A receptors (GABA(A)Rs) producing membrane depolarization, which promotes calcium entry, dendritic outgrowth and synaptogenesis. As development proceeds, GABAergic...

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Pubblicato in:Neuropharmacology
Autori principali: Brady, Megan L., Pilli, Jyotsna, Lorenz-Guertin, Joshua M., Das, Sabyasachi, Moon, Charles E., Graff, Nicholas, Jacob, Tija C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739058/
https://ncbi.nlm.nih.gov/pubmed/29074304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.10.022
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