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Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells

Methylation at cytosine (5mC) is a fundamental epigenetic DNA modification recently associated with iAs-mediated carcinogenesis. In contrast, the role of 5-hydroxymethylcytosine (5hmC), the oxidation product of 5mC in iAs-mediated carcinogenesis is unknown. Here we assess the hydroxymethylome in iAs...

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Bibliografiska uppgifter
I publikationen:Toxicol Appl Pharmacol
Huvudupphovsmän: Rea, Matthew, Gripshover, Tyler, Fondufe-Mittendorf, Yvonne
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738917/
https://ncbi.nlm.nih.gov/pubmed/29175454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2017.11.015
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