Selective targeting of CREB‐binding protein/β‐catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle

BACKGROUND AND PURPOSE: Asthma is a heterogeneous chronic inflammatory disease, characterized by the development of structural changes (airway remodelling). β‐catenin, a transcriptional co‐activator, is fundamentally involved in airway smooth muscle growth and may be a potential target in the treatm...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Koopmans, Tim, Crutzen, Stijn, Menzen, Mark H, Halayko, Andrew J, Hackett, Tillie‐Louise, Knight, Darryl A, Gosens, Reinoud
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738668/
https://ncbi.nlm.nih.gov/pubmed/27629364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13620
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