Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

The power of human induced pluripotent stem cell (hiPSC)-based studies to resolve the smaller effects of common variants within the size of cohorts that can be realistically assembled remains uncertain. We identified and accounted for a variety of technical and biological sources of variation in a l...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Hoffman, Gabriel E., Hartley, Brigham J., Flaherty, Erin, Ladran, Ian, Gochman, Peter, Ruderfer, Douglas M., Stahl, Eli A., Rapoport, Judith, Sklar, Pamela, Brennand, Kristen J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738408/
https://ncbi.nlm.nih.gov/pubmed/29263384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02330-5
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