Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

Loss of 4E-BP1 expression has been linked to cancer progression and resistance to mTOR inhibitors, but the mechanism underlying 4E-BP1 downregulation in tumors remains unclear. Here we identify Snail as a strong transcriptional repressor of 4E-BP1. We find that 4E-BP1 expression inversely correlates...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Wang, Jun, Ye, Qing, Cao, Yanan, Guo, Yubin, Huang, Xiuping, Mi, Wenting, Liu, Side, Wang, Chi, Yang, Hsin-Sheng, Zhou, Binhua P., Evers, B. Mark, She, Qing-Bai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738350/
https://ncbi.nlm.nih.gov/pubmed/29263324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02243-3
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