Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

VEGFR-2/Notch signalling regulates angiogenesis in part by driving the remodelling of endothelial cell junctions and by inducing cell migration. Here, we show that VEGF-induced polarized cell elongation increases cell perimeter and decreases the relative VE-cadherin concentration at junctions, trigg...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cao, Jiahui, Ehling, Manuel, März, Sigrid, Seebach, Jochen, Tarbashevich, Katsiaryna, Sixta, Tomas, Pitulescu, Mara E., Werner, Ann-Cathrin, Flach, Boris, Montanez, Eloi, Raz, Erez, Adams, Ralf H., Schnittler, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738342/
https://ncbi.nlm.nih.gov/pubmed/29263363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02373-8
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