Median regression spline modeling of longitudinal FEV(1) measurements in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients

RATIONALE: Clinical phenotyping, therapeutic investigations as well as genomic, airway secretion metabolomic and metagenomic investigations can benefit from robust, nonlinear modeling of FEV(1) in individual subjects. We demonstrate the utility of measuring FEV(1) dynamics in representative cystic f...

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Bibliographic Details
Published in:PLoS One
Main Authors: Conrad, Douglas J., Bailey, Barbara A., Hardie, Jon A., Bakke, Per S., Eagan, Tomas M. L., Aarli, Bernt B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738083/
https://ncbi.nlm.nih.gov/pubmed/29261779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190061
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