Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

BACKGROUND: The 5′-methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and polyamine metabolism and in the methionine salvage pathway, is considered as a potential drug target against cancer and trypanosomiasis. In fact, Trypanosoma and Leishmania parasites lack de novo purine pat...

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Detaylı Bibliyografya
Yayımlandı:BMC Struct Biol
Asıl Yazarlar: Abid, Hela, Harigua-Souiai, Emna, Mejri, Thouraya, Barhoumi, Mourad, Guizani, Ikram
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738077/
https://ncbi.nlm.nih.gov/pubmed/29258562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-017-0079-7
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