Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome

Oxidative stress has pervasive effects on cells but how they respond transcriptionally upon the initial insult is incompletely understood. We developed a nuclear walk-on assay that semi-globally quantifies nascent transcripts in promoter-proximal paused RNA polymerase II (Pol II). Using this assay i...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Nilson, Kyle A., Lawson, Christine K., Mullen, Nicholas J., Ball, Christopher B., Spector, Benjamin M., Meier, Jeffery L., Price, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737879/
https://ncbi.nlm.nih.gov/pubmed/28977633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx724
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