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Pharmacodynamics and pharmacokinetics of ticagrelor vs. clopidogrel in patients with acute coronary syndromes and chronic kidney disease

BACKGROUND: Pivotal clinical trials found that ticagrelor reduced ischaemic complications to a greater extent than clopidogrel, and also that the benefit gradually increased with the reduction in creatinine clearance. However, the underlying mechanisms remains poorly explored. METHODS: This was a si...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Wang, Heyang, Qi, Jing, Li, Yi, Tang, Yunbiao, Li, Chao, Li, Jing, Han, Yaling
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736840/
https://ncbi.nlm.nih.gov/pubmed/28921624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13436
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