Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

Ruminococcus gnavus is a human gut symbiont wherein the ability to degrade mucins is mediated by an intramolecular trans-sialidase (RgNanH). RgNanH comprises a GH33 catalytic domain and a sialic acid-binding carbohydrate-binding module (CBM40). Here we used glycan arrays, STD NMR, X-ray crystallogra...

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Publié dans:Nat Commun
Auteurs principaux: Owen, C. David, Tailford, Louise E., Monaco, Serena, Šuligoj, Tanja, Vaux, Laura, Lallement, Romane, Khedri, Zahra, Yu, Hai, Lecointe, Karine, Walshaw, John, Tribolo, Sandra, Horrex, Marc, Bell, Andrew, Chen, Xi, Taylor, Gary L., Varki, Ajit, Angulo, Jesus, Juge, Nathalie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736709/
https://ncbi.nlm.nih.gov/pubmed/29259165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02109-8
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