Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic

The treatment of progressive multiple sclerosis (MS) is unsatisfactory. One reason is that the drivers of disease, which include iron-mediated neurotoxicity, lymphocyte activity, and oxidative stress, are not simultaneously targeted. Here we present a systematic screen to identify generic, orally av...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Faissner, Simon, Mishra, Manoj, Kaushik, Deepak K., Wang, Jianxiong, Fan, Yan, Silva, Claudia, Rauw, Gail, Metz, Luanne, Koch, Marcus, Yong, V. Wee
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736601/
https://ncbi.nlm.nih.gov/pubmed/29259169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02119-6
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