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Development of Noviomimetics that Modulate Molecular Chaperones and Manifest Neuroprotective Effects
Heat shock protein 90 (Hsp90) is a chaperone under investigation for the treatment of cancer and neurodegenerative diseases. Neuroprotective Hsp90 C-terminal inhibitors derived from novobiocin (novologues) include KU-32 and KU-596. These novologues modulate molecular chaperones and result in an indu...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5736410/ https://ncbi.nlm.nih.gov/pubmed/29137866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.10.038 |
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