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Anesthetic Isoflurane Induces DNA Damage Through Oxidative Stress and p53 Pathway

DNA damage is associated with aging and neurological disorders, including Alzheimer’s disease. Isoflurane is a commonly used anesthetic. It remains largely unknown whether isoflurane induces DNA damage. Phosphorylation of the histone protein H2A variant X at Ser139 (γH2A.X) is a marker of DNA damage...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Ni, Cheng, Li, Cheng, Dong, Yuanlin, Guo, Xiangyang, Zhang, Yiying, Xie, Zhongcong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736399/
https://ncbi.nlm.nih.gov/pubmed/27194299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-016-9937-8
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