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An RNA Interference Screen Identifies Druggable Regulators of MeCP2 Stability
Alterations in gene dosage due to copy-number variation (CNV) are associated with autism spectrum disorder (ASD), intellectual disability (ID) and other psychiatric disorders. The nervous system is so acutely sensitive to the dose of methyl-CpG-binding protein 2 (MeCP2) that even a two-fold change i...
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| Publicado no: | Sci Transl Med |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5736385/ https://ncbi.nlm.nih.gov/pubmed/28835516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf7588 |
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