Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial

BACKGROUND: We have previously shown that radiotherapy (RT) augments natural killer (NK) functions in pre-clinical models of human and mouse cancers, including sarcomas. Since dogs are an excellent outbred model for immunotherapy studies, we sought to assess RT plus local autologous NK transfer in c...

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Gepubliceerd in:J Immunother Cancer
Hoofdauteurs: Canter, Robert J., Grossenbacher, Steven K., Foltz, Jennifer A., Sturgill, Ian R., Park, Jiwon S., Luna, Jesus I., Kent, Michael S., Culp, William T. N., Chen, Mingyi, Modiano, Jaime F., Monjazeb, Arta M., Lee, Dean A., Murphy, William J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735903/
https://ncbi.nlm.nih.gov/pubmed/29254507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-017-0305-7
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