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Entropy and Polarity Control the Partition and Transportation of Drug-like Molecules in Biological Membrane

Partition and transportation of drug in the plasma membrane of a mammalian cell are the prerequisite for its function on target protein. Therefore, comprehensive understanding of the physicochemical properties and mechanism behind these complex phenomena is crucial in pharmaceutical research. By usi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhu, Qiang, Lu, Yilin, He, Xibing, Liu, Tao, Chen, Hongwei, Wang, Fang, Zheng, Dong, Dong, Hao, Ma, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735159/
https://ncbi.nlm.nih.gov/pubmed/29255188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18012-7
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