Postsynaptic Synaptotagmins Mediate AMPA Receptor Exocytosis During LTP

Strengthening of synaptic connections by NMDA-receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory. During NMDA-receptor-dependent LTP induction, Ca(2+)-influx stimulates recruitment of synaptic AMPA-receptors, thereby strengthening synapses. How Ca...

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Pubblicato in:Nature
Autori principali: Wu, Dick, Bacaj, Taulant, Morishita, Wade, Goswami, Debanjan, Arendt, Kristin L., Xu, Wei, Chen, Lu, Malenka, Robert C., Südhof, Thomas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734942/
https://ncbi.nlm.nih.gov/pubmed/28355182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21720
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