Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid

Soluble forms of oligomeric beta-amyloid (Aβ) are thought to play a central role in Alzheimer’s disease (AD). Transgenic manipulation of methylation of the serine/threonine protein phosphatase, PP2A, was recently shown to alter the sensitivity of mice to AD-related impairments resulting from acute e...

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Udgivet i:PLoS One
Main Authors: Asam, Kesava, Staniszewski, Agnieszka, Zhang, Hong, Melideo, Scott L., Mazzeo, Adolfo, Voronkov, Michael, Huber, Kristen L., Pérez, Eduardo, Stock, Maxwell, Stock, Jeffry B., Arancio, Ottavio, Nicholls, Russell E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734769/
https://ncbi.nlm.nih.gov/pubmed/29253878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189413
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