First-in-Human Treatment With a Dendritic Cell-targeting Lentiviral Vector-expressing NY-ESO-1, LV305, Induces Deep, Durable Response in Refractory Metastatic Synovial Sarcoma Patient

Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor mo...

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Bibliographic Details
Published in:J Immunother
Main Authors: Pollack, Seth M., Lu, Hailing, Gnjatic, Sacha, Somaiah, Neeta, O’Malley, Ryan B., Jones, Robin L., Hsu, Frank J., ter Meulen, Jan
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2017
Subjects:
Case Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733794/
https://ncbi.nlm.nih.gov/pubmed/28891906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000183
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