The allosteric glycogen synthase kinase-3 inhibitor NP12 limits myocardial remodeling and promotes angiogenesis in an acute myocardial infarction model

A key feature of acute myocardial infarction (AMI) is an alteration in cardiac architecture. Signaling events that result in the inhibition of glycogen synthase kinase-3 (GSK-3)β represent an adaptive response that might limit the extent of adverse remodeling in the aftermath of AMI. Here, we report...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Baruah, Jugajyoti, Hitzman, Ryan, Zhang, Jane, Chaudhuri, Suhnrita, Mastej, Victoria, Wary, Kishore K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733612/
https://ncbi.nlm.nih.gov/pubmed/29070680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814376
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