Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia

[Image: see text] Scaffold hopping from the amide group of lead compound ONO-7300243 (1) to a secondary alcohol successfully gave a novel chemotype lysophosphatidic acid receptor 1 (LPA(1)) antagonist 4. Wash-out experiments using rat isolated urethra showed that compound 4 possesses a tight binding...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Terakado, Masahiko, Suzuki, Hidehiro, Hashimura, Kazuya, Tanaka, Motoyuki, Ueda, Hideyuki, Hirai, Keisuke, Asada, Masaki, Ikura, Masahiro, Matsunaga, Naoki, Saga, Hiroshi, Shinozaki, Koji, Karakawa, Naoko, Takada, Yuka, Minami, Masashi, Egashira, Hiromu, Sugiura, Yoshihiro, Yamada, Masanori, Nakade, Shinji, Takaoka, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733272/
https://ncbi.nlm.nih.gov/pubmed/29259748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00383
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