Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP

Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-related mutation, V18M, reduces ChAT enzyme activity and cellular protein levels...

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Udgivet i:Front Mol Neurosci
Main Authors: Morey, Trevor M., Winick-Ng, Warren, Seah, Claudia, Rylett, R. Jane
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733026/
https://ncbi.nlm.nih.gov/pubmed/29311808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00415
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