SGK1 is a critical component of an AKT-independent pathway essential for PI3K-mediated tumor development and maintenance

Activation of the PI3K-AKT signaling cascade is a common critical event during malignant transformation. In this study, we used thyroid gland epithelial cells and a series of genetically engineered mouse strains as model systems to demonstrate that, while necessary, AKT activation is not sufficient...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Orlacchio, Arturo, Ranieri, Michela, Brave, Martina, Arciuch, Valeria Antico, Forde, Toni, De Martino, Daniela, Anderson, Karen E., Hawkins, Phillip, Di Cristofano, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732884/
https://ncbi.nlm.nih.gov/pubmed/29055016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2105
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