NF-kB promotes ovarian tumorigenesis via classical pathways that support proliferative cancer cells and alternative pathways that support ALDH+ cancer stem-like cells

Understanding the mechanisms supporting tumor-initiating cells (TIC) is vital to combat advanced stage recurrent cancers. Here we show that in advanced ovarian cancers NF-kB signaling via the RelB transcription factor supports TIC populations by directly regulating the cancer stem-like associated en...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: House, Carrie D., Jordan, Elizabeth, Hernandez, Lidia, Ozaki, Michelle, James, Jana M., Kim, Marianne, Kruhlak, Michael J., Batchelor, Eric, Elloumi, Fathi, Cam, Margaret C., Annunziata, Christina M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732863/
https://ncbi.nlm.nih.gov/pubmed/29074539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0366
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